The long-running animated series has tapped Tatum, Apatow, Rudd, Leslie Mann, Seth Rogen as well as Judas Priest's frontman Rob Halford to appear in the same episode, reported Aceshowbiz.
They all join Will Arnett who has been earlier announced to lend his voice for the episode.
According to reports, the story begins with Homer illegally downloading films and screening them in his backyard for folks in Springfield after he's fed up with movie theaters.
But an overzealous FBI director in charge of anti-piracy (Arnett) doesn't see it that way and has his eyes on Homer.
One of the movies that Homer screens is a "This is 40" -esque dramedy titled "Life is Funny" that stars Mann and Rudd. Halford sings a parody of the Judas Priest classic "Breaking the Law" and Apatow testifies against Homer "with a hilarious, self-important speech about Hollywood people."
Rogen and Tatum, meanwhile, will appear as themselves.
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