The 40-year-old TV star wed Patrick in the presence of family and friends, reported Us magazine.
"It was very small and quiet," a source said.
Knight's former co-star and close friend Katherine Heigl attended the ceremony. The blonde beauty played Dr Isobel Stevens while Knight became known for his part as Dr George O'Malley on the medical drama which catapulted him into the spotlight.
The actor is currently starring as Mercutio in a production of 'Romeo & Juliet' in New York City and although his co-stars, including Elizabeth Olsen and William Hurt, were unable to attend the ceremony they congratulated him on the happy occasion.
Knight first came out as gay in a statement in 2006 in a bid to clarify any rumours which were developing about him.
"I guess there have been a few questions about my sexuality, and I'd like to quiet any unnecessary rumors that may be out there. While I prefer to keep my personal life private, I hope the fact that I'm gay isn't the most interesting part of me," he had said.
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