The train failed to stop as it pulled into the transit hub of Hoboken, just over the Hudson river from New York, according to early photographs of the accident released by AFP.
"Due to a NJ Transit train derailment at #Hoboken Station, NJ, all PATH train service in and out of Hoboken Station is suspended," New York's official emergency information system tweeted.
New Jersey's emergency management system was reporting more than 100 people injured, while the New Jersey transit service said there were "multiple" injuries, ABC News reported.
Video showed the station in shambles with the train tangled in wires and debris from what appeared to be collapsed portions of the roof.
Emergency vehicles converged on the scene in response to the crash.
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