"I am pleased to nominate (Dr) Seema Verma to serve as Administrator of the Centers for Medicare and Medicaid Services," Trump said in a statement.
The announcement came along with Trump's nomination of Congressman Tom Price as his Health and Human Services Secretary.
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"She has decades of experience advising on Medicare and Medicaid policy and helping states navigate our complicated systems. Together, Chairman Price and Seema Verma are the dream team that will transform our healthcare system for the benefit of all Americans," Trump said.
"I am honoured to be nominated by President-elect Trump today," said Verma, who met Trump in New York last week.
"I look forward to helping him tackle our nation's daunting healthcare problems in a responsible and sustainable way," she said.
Verma currently is the president, CEO and founder of SVC, Inc, a national health policy consulting company.
Based in Indianapolis, Verma has supported Indiana through development of the historic programme since its inception in 2007, from development of the enabling legislation, negotiating the financing plan with the state's hospital association, developing the federal waiver, supporting federal negotiations and leading the implementation of the programme, including the operational design.
For more than 20 years, she has worked extensively on a variety of policy and strategic projects involving Medicaid, insurance, and public health, working with Governors' offices, state medicaid agencies, state health departments, state departments of insurance, as well as the federal government, private companies and foundations.
"Verma has extensive experience redesigning Medicaid programmes in several states. Verma is the architect of the Healthy Indiana Plan (HIP), the nation's first consumer directed Medicaid programme under Governor Mitch Daniels of Indiana and then-Governor Pence's HIP 2.0 waiver proposal," said the presidential transition team.
Verma received her Master's degree in Public Health, with a concentration in health policy and management from Johns Hopkins University, and her Bachelor's degree in Life Sciences from the University of Maryland.
She served as the state of Indiana's health reform lead following the passage of Obamacare in 2010.
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Verma is a graduate of the Richard G Lugar Excellence in Public Service Series, and in 2016, Vice President-elect Mike Pence awarded her the Sagamore of the Wabash.
Additionally, Verma was recently selected to participate in the American Enterprise Institute Leadership Network.
Prior to consulting, Verma served as Vice President of Planning for the Health andHospital Corporation of Marion County and as a Director with the Association of State and Territorial Health Officials (ASTHO) in Washington D.C.
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