He "passed away from natural causes" at Cedars-Sinai medical center, according to his agent John S Kelly.
Despite over 150 television and film appearances spanning six decades, including roles in the "Alien," "The Green Mile," "Pretty in Pink" and "The Avengers," Stanton was not a household name -- though his weathered, drooping face is instantly recognisable.
One of his rare leading roles came in the 1984 road movie "Paris, Texas" where his turn as a father suffering from amnesia helped director Wim Wenders win the 1984 Palme D'Or.
"The great Harry Dean Stanton has left us. There went the great one," the filmmaker Lynch wrote in a statement posted on Twitter.
Stanton's more recent work includes playing polygamist patriarch Roman Grant in TV's "Big Love" and a voice role in animated feature "Rango" with Johnny Depp.
A keen musician, he also founded the eclectic "The Harry Dean Stanton Band" known for its mix of mariachi, jazz and other genres.
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