Mike, a two-year-old, died of a virus "despite the heroic efforts of our veterinary and animal care staff," Ringling Brothers said in a statement yesterday.
Animal rights group Peta said that the elephant's death was "no surprise."
Ashley Settles, Ringling's director of veterinary care, said the illness progressed aggressively with Mike beginning to show symptoms on Saturday and dying by Monday.
"No one knows why the virus manifests this way in some elephants, since most elephants harbor the virus and never become ill," she said.
Ringling Brothers announced two weeks ago that it was relocating all its elephants by May to the center, which develops breeding programs and research aimed at the animals' protection.
"Stressful conditions have been linked to the highly fatal disease that killed this calf, which disproportionately impacts captive baby elephants," Rachel Mathews of Peta said.
Peta, which for years has criticized use of elephants in circuses, repeated its call for the company to end its breeding program and put the animals in "a proper accredited sanctuary.
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