The 40-year-old actor, who will reprise the titular role in the Marvel franchise sequel, took to Twitter to break the news.
"Zazie Beetz Effect," along side a hilarious graphic poster which shows the "Atlanta" actress riding on a flying Deadpool.
Beetz will play Domino, the mercenary who tends to support the good guys and is another survivor of a government programme to create the ultimate soldier.
Earlier, Reynolds had tweeted a cryptic picture and captioned it as "Domino Effect", where he arranged Beetz's name in the form of dominoes.
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