Infosys Americas Regional Head (Energy and Services) Alexandre Elvis Rodrigues will replace him.
Pratt, who joined the firm in 2004, has left the company to start his own entrepreneurial venture.
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Pratt has been an integral part of Infosys since 2004 and has played a key role in strengthening its consulting practice, it added.
"Infosys Americas Regional Head (Energy and Services) Alexandre Elvis Rodrigues will take over from Pratt," the Bangalore-based company said.
According to a person in know of the development, Pratt has left Infosys to start his own entrepreneurial venture in management transformation.
Prior to working with Infosys, Pratt worked with Deloitte Consulting and Booz, Allen & Hamilton.
Infosys -- India's second largest software services exporter -- has been witnessing an exodus of its senior-level executives in the past few months.
Earlier in September, Infosys' Head BPO sales Australia Kartik Jayaraman and BPO Head Latin America Humberto Andrade quit the company.
In August, Ashok Vemuri who was heading the company's operations in the Americas put in his papers. Infosys Vice President and financial services head for the Americas Sudhir Chaturvedi also quit the same month.
In July, Infosys Global Sales Head Basab Pradhan announced his decision to quit the firm.
The exits comes in the backdrop of organisational restructuring that executive chairman NR Narayana Murthy is now overseeing after returning to revive the sagging fortunes of the company in June.
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