The suicide attacker drove the car into buildings behind the police station at Domail in Bannu district of Khyber-Pakhtunkhwa province early this morning.
The explosion was heard from several kilometres away.
Two women and a policeman were killed and 27 others, including 10 women and children and nine policemen, were injured, police officials said.
Seven houses were destroyed or damaged by the blast.
Officials said the death toll could rise as some of the injured were in a serious condition. Some of the critically injured were sent to a military hospital.
Twenty people were injured in a powerful explosion at a busy roundabout in a market in Hangu district of Khyber-Pakhtunkhwa province.
According to police, the bomb was planted in a hand cart.
The target of the attack could not immediately be ascertained. Rescue teams rushed the injured to a nearby hospital.
In the lawless Khyber tribal region, independent candidate Shahjee Gul escaped an explosion that occurred near his election office in Jamrud area this morning.
No loss of life was reported in the attack.
No group claimed responsibility for the attacks.
Pakistan has witnessed a sharp surge in violence by the Taliban and other militant groups ahead of the May 11 general election.
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