The incident occurred late last night when the victims were returning from Dera Sacha Pramukh's village Gursar.
The deceased were identified as Meenakshi (16), Laxmi (7), Manju (17) and Rani (27), police said, adding that the injured were rushed to a government hospital in bordering Sriganganagar district.
Police has impounded the truck while the vehicle driver managed to escape from the spot.