State television reported that a 12-year-old girl suicide bomber blew herself up in the bar, killing 20 people and injuring at least 79 in the blast.
An earlier toll put the number of dead at 14.
There was no immediate claim of responsibility for the attack, but the north of the country has been repeatedly targeted by Nigeria-based Boko Haram extremists.
The atrocity came a day after Boko Haram were also blamed for a wave of a attacks on villages across the border in northeastern Nigeria that left at least 25 dead and forced hundreds more to flee their burning homes.
Cameroon's army has joined the regional military offensive against the extremists after suffering repeated deadly raids into its territory.
Maroua -- the commercial hub of the extreme north of Cameroon close to the Nigerian and Chadian borders -- was already reeling after 13 people were killed in twin suicide bombings on Wednesday in a central market and in a nearby neighbourhood by two teenage girls.
A resident told of "a loud explosion", saying they had learnt there was an attack at the Boucan bar, a large and popular nightspot.
Maroua has been under heavy security for months as the threat from Boko Haram has grown, with motorbikes -- which the insurgents often use to stage their raids -- banned from the streets after dark.
Boko Haram has recently stepped up its attacks in the restive Lake Chad region despite a major regional offensive against the extremists.
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