Sanders, 74, now has support of 47 per cent of Democratic primary voters as against 44 per cent people who back Clinton.
A month ago, Clinton, 68, had support of 49 per cent of the Democratic primary voters.
And last summer, Clinton had a lead of 46 points and that of 22 points as recently as two months ago.
This is the first time that Sanders is leading a national poll against Clinton, who not long ago was regularly described as the "presumptive" Democratic nominee, according to the poll released by Fox news ahead of the South Carolina primary on February 27.
"Historically, lesser-known candidates beating establishment candidates in early contests have seen the biggest boost in their national support," said Republican pollster Daron Shaw, who jointly conducted the Fox news poll with Anderson.
Clinton, however, continues to lead in South Carolina where the Democratic primary is scheduled for later this month. But her lead with Sanders has reduced.
In December, Clinton held a 44-point lead (65-21 per cent).
On the Republican side, front runner Donald Trump leads with 36 per cent support from Republican primary voters.
He is followed by Texas Senator Ted Cruz with 19 per cent and Florida Senator Marco Rubio 15 per cent.
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