Barrios, 33, and Qatari track and field athlete Samuel Adelebari Francis, 29, both tested positive for banned substances in tests originally taken at Beijing 2008.
Barrios, 33, won silver in the discus in Beijing. She tested positive for the diuretic and masking agent acetazolamide, and has now been ordered to return her medal. She also won bronze in London 2012.
Nigeria-born Francis, who now represents Qatar, finished 16th in the 100m event. The former Asian 100m champion tested positive for the banned substance stanozolol.
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