Chris Evans and Fearne Cotton hosted the ceremony live from London's Earl's Court, reported Digital Spy.
Sheeran, 23, was victorious in the British Artist of the Year category, triumphing over rock icon David Bowie, Sam Smith, Elbow, Jungle and Royal Blood.
The singer-songwriter's win for British Artist of the Year comes on the heels of his latest record X.
'Happy' star Williams beat out Dolly Parton, Gregory Porter, Lorde, Prince and Taylor Swift to become International Artist of the Year.
Gwen Stefani presented Williams with the award as part of a live video link-up from the set of 'The Voice US' in Los Angeles.
Song of the Year also went to Williams for his global smash 'Happy'.
The night also included live performances from Take That, George Ezra, Coldplay, One Direction and Ella Henderson collaborating on stage with Labrinth.
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