The fighting came as regime forces battled IS in the northern province of Aleppo, repelling a jihadist assault and killing at least 16 fighters from the group.
The Syrian Observatory for Human Rights said IS had advanced into the northern tip of Deir Ezzor city, in eastern Syria, and captured the suburb of Al-Baghaliyeh.
The advance puts IS in control of around 60 per cent of the city, with the regime holding the rest, according to the Britain-based monitor.
Deir Ezzor is the capital of Deir Ezzor province, an oil-rich region that borders Iraq and is mostly held by IS.
The regime has clung onto portions of the provincial capital and the adjacent military airport despite repeated IS attacks.
Observatory chief Rami Abdel Rahman said heavy fighting was continuing today afternoon after the IS assault, which began with a suicide car bomb blast carried out by a member of the jihadist group.
Eight of the regime forces killed were shot dead by IS jihadists, the Observatory added.
Elsewhere, regime troops were locked in fierce clashes with IS in Aleppo province, with at least 16 jihadists killed after a failed attack on a government position near the town of Al-Bab, the Observatory said.
State television also reported that regime forces had repelled an assault.
The Observatory said heavy fighting was ongoing throughout today in the area, with Russian war planes carrying out strikes in the region between the regime-held Kweyris air base and Al-Bab.
The regime has advanced towards the town, an IS bastion, in recent days, and is now within 10 kilometres (six miles) of it, according to the Observatory.
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