J Bala Krishna, his father Chitranjan who is a local Congress activist, and mother Jagadamba, besides his two sisters and brother-in-law were arrested in connection with the murder of J Rajini, they said.
Bala Krishna, who had a relationship with another woman, allegedly killed his wife by slitting her neck with a knife when she was asleep, Chikkadpally police said.
She had been given sleeping pills before the incident, police added.