The demonstration was part of commemorations of a 1968 massacre of students by the army in Mexico City but the protesters focused on the fate of the disappeared in violence-plagued Guerrero state.
Parents of the missing led the march in the state capital Chilpancingo yesterday, holding signs saying "they were taken alive, we want them back," as a sea of students, teachers and others followed behind.
The students, from a teacher training college near Chilpancingo, had gone to the town of Iguala 100 kilometres to the north last Friday to raise funds when they were shot at by municipal police after they hijacked buses to return home.
Authorities detained 22 officers over the shooting and another attack that killed three other people later that night on the outskirts of Iguala.
A gang is believed to have participated in the second shooting and the officers are suspected of having links to criminals in the region, raising fears a gang has the students.
"We are fed up with crime and corruption in this state," said Manuel Martinez, 32, whose 18-year-old nephew is among the missing.
Relatives of the missing, backed by scores of troops and state police, scoured fields and communities around Iguala this week, handing out flyers with pictures of their loved ones.
"The search was a show," said Mariano Flores Vazquez, 35, who searched for his 22-year-old nephew.
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