Series writers John Fawcett and Graeme Manson will team with Jody Houser on the comic, reported Digital Spy.
Spawn artist Szymon Kudranski will join them on the miniseries based on BBC Canada's acclaimed show.
"One. Of a kind. Sarah's life was changed dramatically after witnessing the suicide of a woman who looked just like her," read IDW's solicitation.
"Sarah learned that, not only were she and the woman clones, but there were others just like them, and dangerous factions at work set on capturing them all."
'Orphan Black' will return to television for a third season in spring 2015.