Awami National Party (ANP) leader Abdul Razzaq and his brother Abdul Khaliq were on their way to Pishin to attend a public rally when the explosion took place along the Harnai Shahrag road yesterday, a police officer said.
The two were killed on the spot, Harnai deputy commissioner Abdul Salam said.
The ANP has eight members in total in Parliament.
"It was a roadside explosive detonated when their vehicle was passing through the area," he said.
"Bullock-cart rider Bhagia Khan and a young shepherd, Hadi, stepped on the landmines while passing through the area," a police official said.
In a separate incident, the Lahore-bound Akbar Bugti Express derailed in Mach area of Bolan district when a bomb exploded, the police said.
The bomb was planted near the railway track and six people were injured in the incident, they added.
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