The benchmark Karachi Stock Exchange index of 100 shares lost 2.67 per cent or 905 points to close at 32,986 points.
The index had shed 4.11 per cent during last month's international turmoil sparked by fears over China's slowing economy, and had recovered little ground since then.
"Today the rumours about the potential arrests of stock (market)-related people intensified the panic," said Mohammad Sohail, an analyst and the chief of Topline Securities.
Pakistani authorities have in recent months embarked on an anti-corruption drive, with former prime minister Yousuf Raza Gilani, who held office from 2008-2012, facing 24 graft charges.
Former petroleum minister Asim Hussain, a close aide to ex-president Asif Ali Zardari, was also remanded into the custody of Pakistan's Rangers paramilitary force over another corruption case.
Officials of the state-run Sui Southern Gas Company, one of the exchange's blue chips, were also being questioned by anti-corruption officials.
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