Mohammed bin Ali bin Hayazaa al-Hayazaa replaces Abdullah al-Rabiah who was dismissed in April as concerns grew over the kingdom's handling of the Middle East Respiratory Syndrome coronavirus (MERS-CoV).
Before Hayazaa's appointment as part of a cabinet reshuffle, Labour Minister Adel Fakieh had been serving as acting health minister.
During the tenure of Fakieh, who promised "transparency" over MERS, the World Health Organisation said a surge in MERS cases had receded but urged continued vigilance.
Research by Saudi scientists indicates that camels play a role in the transmission of the virus to humans.
MERS has surfaced in about 20 countries but hit the Gulf kingdom hardest, with 818 cases and 352 deaths since 2012.
The health minister and other new cabinet members were appointed through royal decrees published by the official Saudi Press Agency.
In another key replacement, Abdul Aziz bin Abdullah al-Khudairi takes over the culture and information portfolio after Abdulaziz Khoja was sacked in November.
The decree said Khoja left the job "at his request". His dismissal followed Shiite calls for action against hate speech in the media.
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