Scientists inch closer to blood test for Alzheimer's disease

Researchers are inching closer to a blood test that can accurately detect the presence of Alzheimer's disease, which would give physicians an opportunity to intervene at the earliest, most treatable stage of the disease.
Robert Nagele from the Rowan University School of Osteopathic Medicine in the US is focusing on utilising autoantibodies as blood-based biomarkers to accurately detect the presence of myriad diseases and pinpoint the stage to which a disease has progressed.
The blood test may also be able to detect other diseases, including Parkinson's, multiple sclerosis and breast cancer.
By detecting Alzheimer's disease long before symptoms emerge, Nagele hopes those with disease-related autoantibody biomarkers will be encouraged to make beneficial lifestyle changes that may help to slow development of the disease.

"There are significant benefits to early disease detection because we now know that many of the same conditions that lead to vascular disease are also significant risk factors for Alzheimer's," Nagele said.
"People found to have preclinical disease can take steps to improve their vascular health, including watching their diet, exercising and managing any weight and blood pressure issues to help stave off or slow disease progression," Nagele said.

While the cause of Alzheimer's remains elusive, it is clear that maintaining a healthy blood-brain barrier is a critical preventative measure.
Diabetes, high cholesterol, high blood pressure, stroke and being overweight jeopardise vascular health. As blood vessels in the brain weaken or become brittle with age, they begin to leak, which allows plasma components including brain-reactive autoantibodies into the brain.

There, the autoantibodies can bind to neurons and accelerate the accumulation of beta amyloid deposits, a hallmark of Alzheimer's pathology.
Nagele's research has found that all humans possess thousands of autoantibodies in their blood. These autoantibodies specifically bind to blood-borne cellular debris generated by organs and tissues all over the body.
An individual's autoantibody profile is strongly influenced by age, gender and the presence of specific diseases or injuries; and diseases cause characteristic changes in autoantibody profiles that, when detected, can serve as biomarkers to indicate the presence of the disease, researchers said.
In Alzheimer's, the brain begins to change years before symptoms emerge. Detecting Alzheimer's antibodies at the preclinical stage would give patients an opportunity to work with their physician to make lifestyle changes or receive available treatments before they become symptomatic.

Potentially, this early intervention could help those with preclinical Alzheimer's avoid or delay the most devastating symptoms, researchers said.