The blast struck in the vicinity of the Greek Orthodox Virgin Mary Church in the predominantly Christian neighbourhood of Bab Sharqi in central Damascus, according to state TV. It said several people also were wounded in the explosion, but gave no further details.
A government official told The Associated Press that the suicide attacker was wearing an explosive belt and blew himself up near the church. Both the official, who spoke on condition of anonymity in line with regulations, and state TV said at least four people were killed.
Lebanon's Al-Mayadeen TV, which has reporters in Damascus, said the target of the attack appeared to be a nearby post of the National Defence Forces, a paramilitary force fighting against rebels trying to topple President Bashar Assad.
Churches have been targeted in the past, mostly in the central city of Homs and Syria's largest city of Aleppo in the north.
In April, two bishops were kidnapped in northern Syria. They are still missing.
Christians are one of the largest religious minorities in the country, composing about 10 per cent of Syria's population of 23 million people. They have tried to stay on the sidelines of the conflict, although the opposition's increasingly outspoken Islamism has prompted many to lean toward the regime.
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