Developed in consultation with President Trump's national security team, the new strategy is the culmination of nine months of deliberation with Congress and US allies on how to best protect American security, the White House said.
Trump is scheduled to address the nation on the new Iran strategy later tonight.
"Most importantly, we will deny the Iranian regime all paths to a nuclear weapon," the White House said.
"We will work to deny the Iranian regime and especially the Islamic Revolutionary Guard Corps (IRGC) funding for its malign activities...We will counter threats to the US and our allies from ballistic missiles and other asymmetric weapons," the White House said.
The new strategy does not declare the IRGC a terrorist organisation, but says the US will rally the global community to condemn the IRGC's gross violations of human rights and its unjust detention of American citizens and other foreigners.
Even with regard to JCPOA itself, the Iranian regime has displayed a disturbing pattern of behaviour, seeking to exploit loopholes and test the international communitys resolve, alleged the Trump Administration.
The Joint Comprehensive Plan of Action (JCPOA), known as Iran nuclear deal, was signed by Iran and 5+1 group of countries (Britain, China, France, Russia, the US and Germany) in 2015 under which Iran agreed to freeze its nuclear programme for 15 years in exchange for sanctions relief.
"Not long ago these same organisations hid nuclear facilities on military sites. This behaviour cannot be tolerated; the deal must be strictly enforced, and the IAEA must fully utilise its inspection authorities," it said.
Underscoring the need for a comprehensive strategy, the White House alleged that the previous administration's myopic focus on Iran's nuclear programme to the exclusion of the regime's many other malign activities allowed Iran's influence in the region to reach a high-water mark.
In doing so, the United States has neglected Irans steady expansion of proxy forces and terrorist networks aimed at keeping its neighbours weak and unstable in hopes of dominating the greater Middle East, the White House rued.
"The Trump administration will not repeat these mistakes," the White House said.
The Trump administration will accomplish these objectives through a strategy that neutralises and counters Iranian threats, particularly those posed by the IRGC.
The reckless behaviour of the Iranian regime, and the IRGC in particular, poses one of the most dangerous threats to the interests of the US and to regional stability, it claimed.
It said the Iranian regime has taken advantage of regional conflicts and instability to aggressively expand its regional influence and threaten its neighbours with little domestic or international cost for its actions.
It also includes consistently threatening freedom of navigation, especially in the Persian Gulf; cyber-attacks against the US, Israel, and Americas other allies and partners in the Middle East; grievous human rights abuses; and arbitrary detention of foreigners, including United States citizens, on specious charges and without due process.
Countering IRGC would be one of the key element of this new strategy.
"For all these reasons, we want to work with our partners to constrain this dangerous organisation," it said.
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