The killing of Michael Brown,18, in August had resulted in large scale violence in certain parts of the State.
A grand jury decision is expected anytime now.
The decision by the Missouri Governor Jay Nixon to declare emergency is seen as a preventive measure to prevent any violence in this sensitive state now.
In the days after the fatal shooting of Brown by police officer Darren Wilson, resulted in a large scale violence, looting and street protests in the streets of St Louis and its suburbs.
The Governor said the Guard will provide support for law enforcement's objectives of maintaining safety and protecting constitutional rights.
"As part of our ongoing efforts to plan and be prepared for any contingency, it is necessary to have these resources in place in advance of any announcement of the grand jury's decision," Nixon said.
"These additional resources will support law enforcement's efforts to maintain peace and protect those exercising their right to free speech," he said.
"All people in the St Louis region deserve to feel safe in their communities and to make their voices heard without fear of violence or intimidation. Public safety demands that we are fully prepared for any contingency, regardless of what the St Louis County grand jury or the US Department of Justice decides," he said.
The St Louis County prosecutor has said publicly that an announcement of the grand jury's decision will be made later this month.
"Our department, like other police departments in the region, has a full time job keeping our neighbourhoods safe. We are used to working with other agencies in times of necessity," said St Louis Metropolitan Police Chief Sam Dotson.
"Having the support of the National Guard available will enable local officers to continue to respond promptly to calls for service," said St Louis County Police Chief Jon Belmar.
