Fore, 69, has worked to champion economic development, education and health, humanitarian assistance and disaster relief for the most vulnerable in the international and developing world.
She was the first woman to be appointed Administrator of the US Agency for International Development and Director of US Foreign Assistance in the Department of State, she held these positions between 2006 and 2009.
From 1989 to 1993, she was working as the USAID Assistant Administrator for Asia and for Private Enterprise.
In addition, she was member on the boards of the Overseas Private Investment Corporation and the Millennium Challenge Corporation.
Welcoming her appointment as UNICEF head, State Department Spokesperson Heather Nauert said that Fore will be a "powerful" voice on behalf of the world's children in her new position with the UN.
She will succeed Anthony Lake.
"Henrietta Fore will bring a wealth of experience to UNICEF's work for children. I know the organisation will support her as it has worked with me. Her success will be UNICEFs success and thus a success for children," said Lake, whose term ends on December 31.
The Trump administration has welcomed the UN's decision.
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