"Fourteen leaders, fourteen role models, fourteen women of courage, one crystal clear message," said Secretary of State John Kerry.
"Don't accept the unacceptable or wait for someone else to step up. Act in the name of justice. Act in the name of tolerance. Act on behalf of truth."
All but one of the honorees were able to attend the ceremony in Washington, an annual event that began in 2007 to encourage women's empowerment.
Bangladeshi barrister Sara Hossain helped draft her country's laws on violence against women and has argued landmark rights cases before the supreme court.
Ni Yulan, a disabled Chinese property rights lawyer, was the only honoree not to receive her award in person, having been forbidden from traveling by her government.
France's Latifa Ibn Ziaten became an activist promoting interfaith dialogue in 2012 after her soldier son was slain by Islamist extremist Mohamed Merah.
Attorney General Thelma Aldana of Guatemala began her career as a courtroom janitor and has now brought corruption charges against the highest in the land.
Nagham Nawzat Hasan is an Iraqi gynecologist and a member of the country's persecuted Yazidi minority. She works with girls kidnapped and raped by Islamist militants.
Mauritania's first female attorney Fatimata M'baye was honoured as co-founder and president of the Mauritanian Association for Human Rights and fights slavery.
Russian journalist Zhanna Nemtsova has braved death threats to campaign for justice for her father, former deputy prime minister Boris Nemtsov, assassinated last year.
Zuzana Stevulova, director of the Human Rights League of Slovakia, is the foremost champion of the rights of refugees flowing into Europe from war in the Middle East.
Awadeya Mahmoud, founder of the Women's Food and Tea Sellers' Cooperative in Sudan has championed the rights of small businesswomen against authoritarian government
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