| Group 1 | Group 2 |
| Mumbai Indians | Chennai Super Kings |
| Kolkata Knight Riders | Sunrisers Hyderabad |
| Rajasthan Royals | Royal Challengers Bangalore |
| Delhi Capitals | Punjab Kings |
| Lucknow Super Giants | Gujarat Titans |
Each team will play all the teams in its own group twice and the team parallel to it in the other group twice. And for the rest of the teams in the other group, the said team will play them only once. For e.eg MI will play all the teams in its group twice and Chennai Super Kings from the other group twice as well, but the other four teams from Group 1 will play MI only once.
| Versus (Team) | Venue | Date and Time (IST) | Match Number |
| Delhi Capitals | Brabourne-CCI, Mumbai | 27.03.2022, 1530 hrs | 02 |
| Rajasthan Royals | DY Patil Stadium, Navi Mumbai | 02.04.2022, 1530 hrs | 09 |
| Kolkata Knight Riders | MCA Stadium, Pune | 06.04.2022, 1930 hrs | 14 |
| Royal Challengers Bangalore | MCA Stadium, Pune | 09.04.2022, 1930 hrs | 18 |
| Punjab Kings | MCA Stadium, Pune | 13.04.2022, 1930 hrs | 23 |
| Lucknow Super Giants | Brabourne-CCI, Mumbai | 16.04.2022, 1930 hrs | 26 |
| Chennai Super Kings | DY Patil Stadium, Navi Mumbai | 21.04.2022, 1930 hrs | 33 |
| Lucknow Super Giants | Wankhede Stadium, Mumbai | 24.04.2022, 1930 hrs | 37 |
| Rajasthan Royals | DY Patil Stadium, Navi Mumbai | 30.04.2022, 1930 hrs | 44 |
| Gujarat Titans | Brabourne-CCI, Mumbai | 06.05.2022, 1930 hrs | 51 |
| Kolkata Knight Riders | DY Patil Stadium, Navi Mumbai | 09.05.2022, 1930 hrs | 56 |
| Chennai Super Kings | Wankhede Stadium, Mumbai | 12.05.2022, 1930 hrs | 59 |
| Sunrisers Hyderabad | Wankhede Stadium, Mumbai | 17.05.2022, 1930 hrs | 65 |
| Delhi Capitals | Wankhede Stadium, Mumbai | 21.05.2022, 1930 hrs | 69 |
Mumbai will obviously be without the services of Jofra Archer for the entire season. Also, the fitness of Suryakumar Yadav has been in doubt for quite some time now, so it will only be clear on the matchday whether or not Surya is fit
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