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Researchers have identified a gene in multiple mammalian species that could pave the way for a highly effective, reversible and non-hormonal male contraceptive for humans and animals. The team at Washington State University (WSU) in the US identified expression of the gene, Arrdc5, in the testes of mice, pigs, cattle and humans. When they knocked out the gene in mice, it created infertility only in the males, impacting their sperm count, movement and shape. "The study identifies this gene for the first time as being expressed only in testicular tissue, nowhere else in the body, and it's expressed by multiple mammalian species," said Jon Oatley, a professor in WSU's School of Molecular Biosciences. "When this gene is inactivated or inhibited in males, they make sperm that cannot fertilise an egg, and that's a prime target for male contraceptive development," said Oatley, senior author of the study published in the journal Nature Communications. While other molecular targets have bee
The endogenous manufacturing of CRISPR components, through greater research, would make India a commercially successful country in the field of Deep Science, according to Girish Krishnamurthy, CEO & MD, Tata Medical and Diagnostics Ltd.Participating in a panel discussion on 'Gene-Editing On Centre Stage' at the 'Bengaluru Tech Summit 2021', Krishnamurthy opined that the therapeutics R & D is slow in India as compared to the West, hence seeking deeper research experiences is significant."The country also needs to address associated infrastructural issues like the building of cold storage, expanding supply chains and the sorts," he said.The CEO also highlighted the misconception amongst people that CRISPR is meant for therapeutic and not diagnostic purposes and that it needs to change. With basic technology and market being the most crucial focal points, a large number of its applications are to be looked at, serving both urban and rural India.Though grants are channelized ...