The Syrian state broadcaster said there were several dead and wounded in the strike.
The Syrian opposition blamed the suspected chemical attack on Saturday in the town of Douma on government forces.
As international officials worked to try to confirm the chemical attack, Trump took the rare step of directly criticising Russian President Vladimir Putin in connection with the incident.
Trump said on Sunday there would be a “big price to pay” after medical aid groups reported dozens of civilians, including many children and women, were killed by poison gas in the besieged rebel-held town of Douma.
“Many dead, including women and children, in a mindless Chemical attack in Syria. Area of atrocity is in lockdown and encircled by Syrian Army, making it completely inaccessible to outside world. President Putin, Russia and Iran are responsible for backing Animal Assad. Big price to pay,” Trump wrote on Twitter.