The Syrian Observatory for Human Rights said 12 people, including two children, died in the town of Rouhabiya, northeast of the capital, as regime forces retaliated for a rebel attack on army positions.
The dead also included nine rebel fighters, the Britain-based Observatory said.
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Air strikes and shelling by regime warplanes on other targets in the countryside of Damascus killed nine other people, including three children, the Observatory said.
A woman and two children were also killed when a car bomb exploded in the southern province of Daraa, the Observatory said. State television said it blew up as "terrorists" were planting a bomb inside the vehicle.
According to the Observatory, which collates information from a network of activists and medics, more than 110,000 people have been killed since Syria's conflict broke out in March 2011, including at least 40,146 civilians.
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