The Cessna 310 aircraft landed on Interstate 405, just short of a runway at John Wayne Airport in Costa Mesa around 9:30 am, said Ian Gregor, a spokesman for the Federal Aviation Administration. He said the crash happened under "unknown circumstances."
Orange County Fire Capt Larry Kurtz said two people were aboard the plane when it crashed and were taken to a local hospital.
The two people suffered non-life-threatening injuries, Deanne Thompson, a spokeswoman for John Wayne Airport, told KCBS-TV. The airfield was closed to arrivals after the Friday morning crash.
Photos posted on social media showed flames shooting out of the front of the aircraft and smoke surrounding the plane.
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