In the picture, the 36-year-old 'In Da Club' rapper was seen being surrounded by cuddly toys, including a giraffe, and elephant and a lion in his bed and said he wasn't looking forward to being operated on, reported Ace Showbiz.
Alongside the picture, he tweeted, "I don't want to go into surgery."
Appealing to his friend, champion boxer Floyd Mayweather, for support, he added, "@FloydMayweather call my phone why your phone off (sic)."
Although he is claiming to be ill, the rapper, whose real name is Curtis James Jackson III, reassured fans his latest release is ready.
"I'm in the hospital but my gangsta grillz LOST TAPE is done so it will be out on time (sic)," he added.