The collision left people trapped inside the 72-seat passenger bus which was heading from Lahore to Islamabad.
A Skyways company bus was going to Islambad from Bahawalpur via Lahore-Islamabad motorway when it hit a trolley parked on the side lane, motorway police spokesman Imran Shah told PTI.
Police and rescue officials reached the scene and shifted the injured to hospitals in Rawalpindi and Islamabad.
Doctors pronounced nine persons, including a bus hostess, dead. Among the dead were two children aged five and nine and a bus guard.
There were reportedly 70 passengers in the bus at the time of the accident.
According to the Rescue officials, some 20 passengers are being treated in both hospitals. The condition of four is stated to be critical.
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