The 58-year-old star said it takes strong women to change the perception that career opportunities for actresses decrease with age, reported People magazine.
"By the time you're 40 in Los Angeles, you're over the hill in the business. It takes women that are strong enough to actually change the perception."
Griffith, who was nominated for an Oscar in 1989 for her performance in the women-in-the-workplace empowerment classic "Working Girl", cites Zoe Cassavetes, the director of her latest film, as one example.
"Day Out of Days" sheds light on what it really takes to survive in Tinseltown. Griffith plays an unstable mother/momager to 40-year-old actress/former in-demand starlet Mia Roarke (Alexia Landeau), and emphasizes that the film rightly shows the less-than-glamorous side of the business.
"It's tough, it's not glamorous like it's portrayed. Some of it is glamorous, but honestly, unless you can really enjoy your work, it's too tough. The payback is being able to play and do your job and have fun with it because otherwise it's just too brutal, there's too much judgment and criticism, opinions, it's just brutal.
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