Ayman al-Zawahri told the jihadis to remain steadfast and change tactics in order to wage guerrilla war. His remarks came in an audio message released through al-Qaida's media arm, As-Sahab.
Al-Zawahri said the "international satanic alliance" of state powers would never accept Islam's rule in Syria. He said the war isn't an exclusively nationalist Syrian cause but a campaign by the entire Muslim nation that seeks to establish divine rule.
Al-Qaida's Syria branch formerly the Nusra Front but now known as the Fatah al-Sham Front has come under increasing attack from the US-led coalition in recent months and some of its most senior leaders have been killed in airstrikes.
Government forces have besieged the neighbourhood since 2013, according to the Washington-based monitoring group Siege Watch. Rebels, opposition activists and their families agreed to vacate the district in an agreement signed in March in exchange for the end of hostilities.
The government will retake control of the neighbourhood after the last of twelve rounds of evacuations are complete, in an expected three to four weeks, according to local media activist Osama Abou Zeid.
An estimated 1,800 people, including some 500 fighters, left today, said Abou Zeid. They are being taken to Jarablus, a town on the Turkish border that is under the control of Turkish and Syrian opposition forces.
Areas all over Syria have surrendered to the government in exchange for relief from its sieges. Rebels and dissidents are offered exile to rebel-held areas in northern Syria, if they do not want to reconcile with the authorities.
Another 8,000 people have left two pro-government towns in northern Syria, besieged by rebels, in recent weeks.
Critics say the population transfers are redrawing Syria's map along sectarian and political lines.
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