"The supreme constitutional court announces... The acceptance of candidacy bids registered by... Maher Abdel Hafiz Hajjar, Hassan Abdallah al-Nuri and Bashar Hafez al-Assad," a court official said.
Twenty-three candidates had initially registered to run against Assad, but most did not meet election criteria to run for office in a vote that has been mocked by the opposition and the West as a "farce".
Both Hajjar and Nuri are largely unknown to the Syrian public.
Candidates whose bids were rejected have until May 7 to appeal the court's decision, said Majed al-Khadra of the constitutional court, whose statement was carried by state television.
Among them is the stipulation that anyone who has lived outside Syria in the past decade is excluded, effectively barring most prominent opposition figures, who live in exile.
At the same time, the vote will only be held in areas under government control.
The election is being held amid a brutal civil war that has killed more than 150,000 people since March 2011 and made millions homeless.
The regime has barred from voting those refugees who left the country illegally.
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