There was no claim of responsibility for the three bombings in Jalalabad, the capital of Nangarhar province, which is a hotbed of IS militancy.
"Five people were martyred in three explosions in different parts of Jalalabad of Nangarhar province this morning," provincial spokesman Ataullah Khogyani told AFP.
Khogyani said the first blast was a roadside bomb which detonated outside the house of a senior prison official, Abdul Hakim, killing him and a child and wounding six others.
Khogyani said the third blast came as people gathered at Hakim's house after the first blast, but there were no casualties.
Najib Kamawal, director of the Nangarhar civil hospital confirmed the toll.
The IS group appears to be intensifying attacks against the government and civilians as Afghan forces, backed by NATO air strikes, step up operations against them in Nangarhar.
Last week IS claimed a massive suicide blast targeting Shiites in Kabul that killed at least 27 people.
As well as the emerging threat from IS loyalists, who are making gradual inroads across Afghanistan, Taliban fighters are active in Nangarhar.
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