Police said they had mobilised to the scene in Lower Manhattan and that one person was in custody, giving no further details.
The incident happened in the area of Chambers and West Streets in the upmarket TriBeCa neighbourhood.
US media said a gunman opened fire from a vehicle not far from Stuyvesant High School. Witnesses said they saw a car crash, one person exit one of the cars carrying two guns, before they heard shots.
New York Mayor Bill de Blasio was en route to the scene of the incident and there was "no active threat," a spokesman tweeted.
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