Spain star Fabregas came off during the Blues' League Cup semi-final victory over Liverpool with a hamstring injury and missed the draw with Manchester City and Saturday's win at Aston Villa.
But Mourinho confirmed Fabregas will be back in midfield for the showdown at Stamford Bridge as the Blues aim to maintain their seven-point lead over City at the top of the table.
"I think he (Fabregas) plays Wednesday because on Saturday it was a decision to protect him," Mourinho said.
In the absence of Fabregas, Ramires had been selected in midfield, alongside Nemanja Matic, following his own return to full fitness and Mourinho admitted it was a great help to have such quality back-up.
"The best Ramires is back and the best Ramires played against Liverpool, Man City and Aston Villa," Mourinho added.
"He is a different profile of player (compared with Fabregas) but he is a fantastic player for us."
"Every striker in the world would be proud to score that magnificent goal," he added.
"For a right-back whose left foot is not his best one it is an amazing goal, especially when it is the winning goal. If you score that goal and it is 3-0 or 4-0 it is a different thing.
"I am very happy because he is a great guy and what he is doing for us is unbelievable with the foot injury he had against Liverpool when he played the rest of the game, and he played against Man City and Aston Villa.
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