Backed by the coalition, loyalists of exiled President Abedrabbo Mansour Hadi have recently made sweeping advances against the Iran-backed Shiite rebels known as Huthis.
They retook the southern port and second city Aden last month, and have seized four additional southern provinces in their advance towards Taez, some 330 kilometres (205 miles) south of Sanaa.
But as combat raged in Taez, the loyalists were hit by a different foe in Aden. Al-Qaeda fighters suspected of having entered the city several weeks ago were blamed for blowing up a building used by the secret police.
Rima Kamal, spokeswoman in Yemen for the International Committee of the Red Cross, said violence in Taez Friday had killed 80 people.
"My colleague was told that by noon yesterday, there were 50 killed; in the evening it went up to 80. These are figures we are receiving from various sides," she told AFP.
Doctors Without Borders said Friday that 65 civilians had been killed and several wounded in bombing runs in Taez's Salah neighbourhood.
The rebel-controlled Saba news agency said the raids had killed 63 civilians and wounded 50.
Kamal said Saturday that "civilians are suffering on multiple fronts. There was an overwhelming number of civilians killed yesterday."
She said shelling and clashes were ongoing, with residents saying fighting around a presidential palace in Taez had killed three civilians.
In Aden, a bomb destroyed the secret police headquarters early Saturday, residents said, in an attack one official blamed on Al-Qaeda.
The four-storey building in Tawahi collapsed under the force of the blast, which was heard across the city.
He claimed AQAP militants had entered Aden just two weeks after it was retaken from the rebels on July 17.
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