The 54-year-old kept gushing about his wife on several occasions while promoting his new film, "Tomorrowland", reported Ace Showbiz.
"She's an amazing human being. And she's caring. And she also happens to be one of the smartest people I've ever met. And she's got a great sense of humour," Clooney said.
Commenting on her being a fashion icon, the star said, "It's amazing, because she's always - since the day I met her - she's always had this insanely ... It's eccentric but it's fun, sense of fashion."
"How she does it while she's got 11 cases she's working on, and she was teaching at Columbia, and she's still like, 'I want to wear that dress.' It's crazy. It has been sort of fascinating to watch, because she has such great taste," he added.