Hamilton's quickest lap of 1 minute, 24.220 seconds yesterday was nearly six-tenths of a second - 0.0583 seconds - faster than new Mercedes teammate Valtteri Bottas.
The two Mercedes cars were followed by the two Red Bulls of Daniel Ricciardo, 0.666 behind, and Max Verstapen in third and fourth and the two Ferraris of Kimi Raikkonen in fifth and Sebastian Vettel, who only did 10 laps and was 1.244 off the pace.
The first practice session supported expectations that the cars will be significantly quicker this year.
Williams rookie Lance Stroll set the first time of the season, the 18-year-old Canadian momentarily on top of the time sheets after his first flying lap in an F1 Grand Prix event before ending the first session in 13th.
His teammate Felipe Massa, here after an aborted retirement, was seventh quickest and was 1.922 behind Hamilton.
Sergio Perez launched the new pink livery for Force India, and posted the 10th fastest time, 2.056 off the pace.
The second practice session was set for later Friday, with a third practice Saturday morning before qualifying in the afternoon for Sunday's GP.
Hamilton, who won back-to-back world championships in 2014 and '15 and narrowly lost to now retired teammate Nico Rosberg last season, completed 22 laps and tested three tires, the soft, super-soft and ultra-soft Pirellis.
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