Indian-origin scientist finds new way to develop better drugs

An Indian-origin researcher has figured out how biomolecules, which holds sugars in the body like scaffolds for reacting with other molecules, can lead to new and better drugs.
The study focused on a certain type of biomolecule built like a nano-Christmas tree. Called a glycoconjugate, it's many branches are bedecked with sugary ornaments.
According to conventional wisdom, the glycoconjugate's lowly "tree" basically holds the sugars in place as they do the important work of reacting with other molecules.
Now, Tarun Dama, a biochemist at Michigan Technological University has discovered that the tree itself - called the scaffold - is a good deal more than a simple prop.

"We had always thought that all the biological function resides in the sugar," said Dam, principal investigator of the Mechanistic Glycobiology Lab at Michigan Tech.
"People didn't appreciate that the scaffolds were active," said Dam.

The discovery opens up new avenues for research, in particular the development of more and better pharmaceuticals.
Glycoconjugates are found naturally in the body, but they are also an important class of drugs that includes anything from cancer treatments to vaccines.
To determine if the scaffold had a role to play in biological reactions, Dam and his team built and tested two types of glycoconjugate molecules.

They had the same sugars and virtually identical shapes but were comprised of different scaffolds, one made of protein, the other a synthetic.
The scientists then tested how the different glycoconjugates reacted with biomolecules called lectins.
Lectins play an important role in numerous biological processes and are a target for many glycoconjugate drugs.
If the scaffolds had been inert, the reactions would have been identical. However, the sugars on the protein scaffold reacted with the lectins differently.
"If the scaffolds are different, they can cause my drug to work one way and your drug to work another way, even though they have similar epitopes (sugars)," Dam said.

"Tweaking the scaffold can change the drug's function," said Dam.
The research was published in the journal Biochemistry.