Itchy inflammation of mosquito bites helps viruses replicate

Mosquito bite sites are not just itchy, irritating nuisances, they also help viruses such as Zika or dengue establish an infection and spread around the body more quickly, increasing the likelihood of severe illness, a new study has found.
The study, led by the University of Leeds in the UK, found that inflammation where the insect has bitten makes viral infections spread by the insects far worse.
"Mosquito bites are not just annoying - they are key for how these viruses spread around your body and cause disease," said Clive McKimmie, a research fellow at University of Leeds.
"We now want to look at whether medications such as anti-inflammatory creams can stop the virus establishing an infection if used quickly enough after the bite inflammation appears," said McKimmie.

Researchers used mouse models to study the bites of the Aedes aegypti mosquito, the species that spreads infections such as Zika, dengue and Chikungunya.
When a mosquito bites, it injects saliva into the skin. The saliva triggers an immune response in which white blood cells called neutrophils and myeloid cells rush to the site.

However, instead of helping, some of these cells get infected and inadvertently replicate the virus, the researchers found.
The team injected viruses into the skin of the mice with or without the presence of a mosquito bite at the injection site and compared the reaction.
In the absence of mosquito bites and their accompanying inflammation, the viruses failed to replicate well, whereas the presence of a bite resulted in a high virus level in the skin.

"This was a big surprise we didn't expect. These viruses are not known for infecting immune cells," said McKimmie, whose team worked alongside colleagues at the University of Glasgow in the UK.
"And sure enough, when we stopped these immune cells coming in, the bite did not enhance the infection anymore," he said.
Despite the enormous disease burden of mosquito-borne viral infections - they are responsible for hundreds of millions of cases across the world - there are few specific therapies or vaccines.
"This research could be the first step in repurposing commonly available anti-inflammatory drugs to treat bite inflammation before any symptoms set in," said McKimmie.

"We think creams might act as an effective way to stop these viruses before they can cause disease," he said.
He added that if it is proven to be effective, this approach could work against a multitude of other viruses.
The study was published in the journal Immunity.