The 30-year-old rapper was rushed to hospital on Friday after suffer from seizures amid reports that his condition was serious, a claim denied by the rapper's family.
Shortly after the news of his hospitalisation broke, Young Money chief Mack Maine tweeted, "Wayne is alive and well!"
Wayne followed it up with a brief tweet.
"I'm good everybody. Thx for the prayers and love."
The rapper, who has been in and out of hospital recently, allegedly suffered seizures because of a "sizzurp" binge.
'Sizzurp' is a mix of cough cyrup, hard candy and soft drinks.