The 24-year-old former One Direction member took to the "X Factor" stage to debut the single along with DJ Steve Aoki, who produced the track, reported Entertainment Weekly.
Despite the emotional timing, Tomlinson performed live as per his mother's final wish.
Amidst a standing ovation, judge Simon Cowell took the moment to reveal his support and adoration for the performer.
"I've known you now for six years. What you've just done and the bravery - I respect you as an artist, I respect you as a person, and your mom was so proud of you, Louis.
Later, Tomlinson thanked his fans on Twitter for their support.
"That was harder than I ever imagined. I want to thank everyone around me and all of the amazing fans out there that made that so special," he wrote.
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