The apparently accidental blaze broke out in the administrative part on the rear facade of the building, the government said, but the debating chamber is believed to have been spared.
The fire was completely out by dawn today, an AFP photographer saw.
"A violent fire devastated the rear facade of the main building of the Ngoa Ekelle Glass Palace last night," Cameroon's public broadcaster CRTV reported, referring to the west African nation's parliamentary building.
The fire broke out around 9:00 pm local time yesterday, and the flames were under control six hours later after causing "a lot of material damage" across four floors but without claiming any casualties.
"The fire was already spreading to the upper levels -- the sixth and seventh floors -- as a helpless crowd looked on."
By today morning the rescue operation was over, but some firefighters remained on the scene which police had sealed off.
Images posted to social media showed flames rising several metres as burning debris shot into the night sky above the blaze.
"The auditorium has not been touched," a police officer told an AFP journalist at the scene.
"According to the clues we have today, the cause of the fire is accidental," Communication Minister Issa Tchiroma Bakary told CRTV.
"The government has taken, and will take, all measures... for the National Assembly to sit as normal without experiencing any disturbance," he added.
Lawmakers have been meeting this week to discuss the country's 2018 budget.
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