Besides, the rupee breaching the 67-mark against the US dollar by plunging 59 paise to 67.22 (intra-day) at the forex market too had its bearing.
Offloading of positions by cautious participants ahead of September IIP data, to be released later in the day, also added to weakened sentiment.
Investors seemed to be cautious on fears that US President-elect Donald Trump's planned huge spending policies would be inflationary which may lead to higher US interest rates and dent the appeal of emerging markets, equity brokers said.
This was the weakest closing since June 29, 2016.
The gauge had rallied 265.15 points in the previous session.
The 50-share NSE Nifty broke 8,300-mark after plunging 229.45 points, or 2.69 per cent, to 8,296.30, its lowest closing since June 30.
For the week, the Sensex dropped 455.33 points, or 1.66 per cent, while the Nifty lost 137.45 points, or 1.62 per cent.
Only Sun Pharma ended in the green territory by recording a rise of 3.30 per cent on the back of better-than-expected quarterly earnings.
Weak earnings from country's largest lender SBI and other bluechip companies also affected the market sentiment, a broker said.
SBI today reported 99.6 per cent dip in consolidated net profit at Rs 20.7 crore for the September quarter. SBI shares slumped 3.09 per cent.
Other Asian markets also ended mixed with Hong Kong's Hang Seng falling 1.35 per cent, while Japan's Nikkei rose 0.18 per cent. Shanghai Composite Index up 0.78 per cent.
European shares were also lower with indices in UK and France were down in their early deals.
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