The 37-year-old actress will reunite with with her Avatar costar Sigourney Weaver for the film, reported Us magazine.
She will play an assassin who is double-crossed by gangsters and finds herself under the scalpel of a rogue surgeon known as 'The Doctor,' who turns him into a woman.
Weaver, 66, will play the doctor.
'Tomboy' was written and will be directed by Walter Hill.
The screenplay will be based on a story by novelist Denis Hamill.
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